Synephrine Hydrochloride Cas:5985-28-4

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Product Description:

Product Name: Synephrine hydrochloride CAS NO: 5985-28-4

 

Synonyms:             

2-methylamino-1-(4-hydroxyphenyl)-ethanol hydrochloride;

(+-)-1-(4-hydroxy-phenyl)-2-methylamino-ethanol,hydrochloride;

4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride;

 

Chemical & Physical Properties:

Appearance: White fine powder

Assay :≥99.0%

Boiling Point: 341.1℃ at 760 mmHg

Melting Point: 147-150℃

Flash Point: 163.4℃

Storage Condition: Refrigerator

 

Safety Information:

HS Code: 2922199090

 

A α-adrenergic receptor agonist, vasoconstrictor. Synephrine Hcl(Oxedrine) is an alkaloid; synephrine produces most of its biological effects by acting as an agonist at adrenergic receptors.IC50 value:Target: adrenergic receptor agonistThere is some evidence that synephrine also has weak activity at 5-HT receptors, and that it interacts with TAAR1 (trace adrenergic amine receptors). d-synephrine inhibited the uptake of [3H]-norepinephrine with an IC50 = 5.8 μM; l-synephrine was less potent (IC50 = 13.5 μM). d-Synephrine also competitively inhibited the binding of nisoxetine[m] to rat brain cortical slices, with a Ki = 4.5 μM; l-synephrine was less potent (Ki = 8.2 μM). In experiments on the release of [3H]-norepinephrine from rat brain cortical slices, however, the l-isomer of synephrine was a more potent enhancer of the release (EC50 = 8.2 μM) than the d-isomer (EC50 = 12.3 μM). This enhanced release by l-synephrine was blocked by nisoxetine.

 

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