PZM21 Cas:1997387-43-5

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Product Description:

Product Name: PZM21 CAS NO: 1997387-43-5

 

Synonyms:

1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea;

1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea;

 

Chemical & Physical Properties:

Appearance: White to off-white solid powder

Assay :≥98.0%

Boiling Point: 583.8±50.0℃(Predicted)

Density: 1.169±0.06 g/cm3 (Predicted)

PKa: 10.06±0.15 (Predicted)

Water Solubility: 10 mM in DMSO

 

PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM. PZM21 is a selective μ receptor agonist (EC50 = 4.6 nM). PZM21 has been reported to exhibit bias for the Gi signaling pathway over arrestin-3. The compound exhibits 500-fold selectivity for μ over δ receptors and no detectable activity at κ or nociceptin receptors and a panel of 316 other GPCRs. PZM21 induces analgesia in a mouse hot plate assay, but not a tail-flick assay and exhibits no significant conditioned place preference response in in vivo assays. CNS penetrant.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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