4-Chloro-3-fluoroaniline

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Chemical Name:    4-Chloro-3-fluoroaniline
CAS.NO: 367-22-6
Synonyms:4-chloro-3-fluoro-aniline;
4-Chlor-3-fluor-anilin;
3-F-4-Cl aniline;
3-Fluoro-4-Chloroaniline;
4-Chloro-3-fluoro-phenylamine;
Molecular Formula:C6H5ClFN
Molecular Weight: 145.56200
 
Physical and Chemical Properties:
Density: 1.349 g/cm3
Melting point: 61ºC 
Boiling point: 234.7ºC at 760 mmHg
Flash point:95.7ºC
Index of Refraction:1.570
 
Specification:
Appearance: White crystalline powder
Purity:≥99.0%
 
Packing:25kg/drum
Storage:Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Application:   used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate; a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase. 4-Chloro-3-fluoroaniline is also used in the synthesis of 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib which is an impurity of the tyrosine kinase inhibitor Gefitinib.

4-Chloro-3-fluoroaniline


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