Chemicals

4-Chloro-3-fluoroaniline

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Chemical Name: 4-Chloro-3-fluoroaniline

CAS.NO: 367-22-6

Synonyms:4-chloro-3-fluoro-aniline;

4-Chlor-3-fluor-anilin;

3-F-4-Cl aniline;

3-Fluoro-4-Chloroaniline;

4-Chloro-3-fluoro-phenylamine;

Molecular Formula:C6H5ClFN

Molecular Weight: 145.56200

Physical and Chemical Properties:

Density: 1.349 g/cm3

Melting point: 61ºC

Boiling point: 234.7ºC at 760 mmHg

Flash point:95.7ºC

Index of Refraction:1.570

Specification:

Appearance: White crystalline powder

Purity:≥99.0%

Packing:25kg/drum

Storage:Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Application: used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate; a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse tranｓｃｒｉｐｔase. 4-Chloro-3-fluoroaniline is also used in the synthesis of 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib which is an impurity of the tyrosine kinase inhibitor Gefitinib.

4-Chloro-3-fluoroaniline

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