Ensartinib Cas:1370651-20-9

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Product Description:

Product Name: ensartinib CAS NO: 1370651-20-9

 

Synonyms:

Ensartinib [USAN: INN];

X-396;

Ensartinib (X-396);

 

Chemical & Physical Properties:

Appearance: Off-white to white solid powder

Assay: ≥98.0%

Density: 1.4±0.1 g/cm3

Solubility: Soluble in DMSO, not in water

Stock Solution Storage: 0 – 4 ℃for short term (days to weeks), or -20℃ for long term (months)

Flash Piont: 382.0±32.9℃

Refractive Index: 1.629

 

 

Ensartinib(cas 1370651-20-9) is a potent inhibitor of ALK, which is used to treat non-small-cell lung cancer. It reduces ALK autophosphorylation and inhibits endogenous ALK phosphorylation and activation of downstream targets ERK and Akt in H3122 cells. Ensartinib reduces growth of H3122 lung cancer cells harboring gain-of-function ALK-fusion proteins (IC50 = 15 nM) but has no effect on cell growth driven by other mutant kinases or that of non-cancerous HepG2 cells.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

 

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