Triclabendazole Cas:68786-66-3

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Triclabendazole

Product Description:

Product Name: Triclabendazole CAS NO: 68786-66-3

 

Synonyms:             

6-CHLORO-5-(2,3-DICHLOROPHENOXY)-2-METHYLTHIO-BENZIMIDAZOLE;

5-CHLORO-6-(2,3-DICHLOROPHENOXY)-2-METHYLTHIO-1H-BENZIMIDAZOLE;

TRICLABENDAZOLE;

 

Chemical & Physical Properties:

Appearance: White to brown crystalline powder

Assay :≥99.0%

Density: 1.59 g/cm3

Boiling Point: 495.9℃ at 760 mmHg

Melting Point: 175 – 176℃

Flash Point: 253.7℃

Refractive Index: 1.724

Storage Condition: 0-6℃

 

Safety Information:

Safety Statements: S26; S36

HS Code: 2933990090

WGK Germany: 3

Risk Statements: R36/37/38

Hazard Code: Xn

 

Triclabendazole (commercial names: veterinary, liquid: Fasinex; human, tablets: Egaten, both manufactured by Novartis) is a member of the benzimidazole family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group. Benzimidazoles such as triclabendazole are generally accepted to bind to beta-tubulin and prevent the polymerization of the microtubules of which they are part.

Triclabendazole was initially only developed as an oral route drug, and displays high efficacy against both immature and adult liver flukes.

Since late 1990s, triclabendazole became available as a generic drug, as patents expired in many countries. Many products were developed then. Among them, Trivantel 15, a 15% triclabendazole suspension, was launched by Agrovet Market Animal Health in the early 2000s. In 2009, the first triclabendazole injectable solution (combined with ivermectin) was developed and launched, also by Agrovet Market Animal Health. The product, Fasiject Plus, a triclabendazole 36% and ivermectin 0.6% solution, is designed to treat infections by Fasciola hepatica (both immature and adult liver flukes), roundworms and ectoparasites, as well.

It is on the World Health Organization”s List of Essential Medicines, the most important medication needed in a basic health system.

 

If you are interested in our products or have any questions, please feel free to contact us!

 

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.



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