5-chloro-1-[(6-benzothiazolyl)sulfonyl]-1H-indole-2-butanoic Acid Cas:927961-18-0

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Product Description:

Product Name: 5-chloro-1-[(6-benzothiazolyl)sulfonyl]-1H-indole-2-butanoic acid CAS NO: 927961-18-0

 

Synonyms:

Lanifibranor (IVA337);

4-(1-(1,3-Benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl)butanoic Acid;

5-chloro-1-[(6-benzothiazolyl)sulfonyl]-1H-indole-2-butanoic acid;

 

Chemical & Physical Properties:

Appearance: Crystalline solid

Assay :≥98.0%

Density   1.56±0.1 g/cm3(Predicted)

Melting Point: 74 – 80℃

Boiling Point: 690.9±65.0℃(Predicted)

PKa: 4.69±0.10(Predicted)

Flash Point: 371.6±34.3℃

Vapor Pressure: 0.0±2.3 mmHg at 25℃

Index of Refraction: 1.727

 

Lanifibranor (IVA-337) is a pan-PPAR agonist with EC50 values of 1537 nM for HPPAR α, 866 nM for HPPAR δ and 206 nM for HPPAR γ, respectively. A PPAR(peroxisome proliferator-activated receptor) activator with EC50 values of 1.5, 0.87, and 0.21μM for human PPARα, PPARσ, and PPARγ, respectively.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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