(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline Cas:118864-75-8

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Product Description:

Product Name: (1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline CAS NO: 118864-75-8

 

Synonyms:

(1S)-1-Phenyl-1,2,3,4-tetrahydro-isopquinoline;

Solifenacin Related Compound 11;

Solifenacin Succinate interMediate F;

 

Chemical & Physical Properties:

Appearance: White solid

Assay :≥99.00%

Density: 1.065

Boiling Point: 338℃

Melting Point: 80-82℃

Flash Point: 167℃

Refractive Index: 1.589

Vapor Pressure: 9.87E-05mmHg at 25℃

 

Safety Information:

HS Code: 2942000000

 

(S) -1-phenyl-1,2,3, 4-tetrahydroisoquinoline can be used to prepare sofinacin. Solifenacin succinate, CAS No. 242478-38-2, chemical name 1-azabicyclic [2.2.2] octan-8-yl -(1S) -1-phenyl-3, 4-dihydro-1H-isoquinoline-2-formate succinate, It is a selective muscarinic M3 receptor antagonist developed by Japan”s Astellas Company. It was first marketed in the Netherlands, Germany, the United Kingdom and Denmark in 2004 and in China in 2009. So far, it has been marketed in more than 50 countries and regions around the world, and has become an important drug for the treatment of bladder overactivity (OAB) in Europe, the United States and Japan. Recommended by multiple authorities and guidelines. Its preparation is as follows: (S) -1-phenyl-3, 4-dihydro-1H-isoquinoline-2-formyl chloride (II) was obtained by condensation of (S) -1-phenyl-1,2,3, 4-tetrahydroisoquinoline (I) with triphosgene under the condition of organic base (weak base). Compound II was heated directly under the catalysis of organic base by one-pot method without separation. Solinacine succinate (IV) was prepared by condensation reaction with (R) -3-quinine cycloalcohol to obtain solinacine (III).

 

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