Valacyclovir Hydrochloride Cas:124832-27-5

We are Valacyclovir Hydrochloride CAS:124832-27-5 manufacturer and supplier in China, Pls send inquiry of to info@nbinno.com of visit www.nbinno.com our official website should you have any interests

Product Description:

Product Name: Valacyclovir hydrochloride CAS NO: 124832-27-5

 

Synonyms:

2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester monohydrochloride;

L-Valine 2-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-ylmethoxy)ethyl Ester Hydrochloride Hydrate;

Valaciclovir;

 

Chemical & Physical Properties:

Appearance: White to off-white crystalline power

Assay :≥99.0%

Density: 1.55g/cm3

Boiling Point: 588.4℃ at 760 mmHg

Melting Point: 170-172℃

Flash Point: 309.7℃

Refractive Index: 1.673

Vapor Pressure: 7.95E-14mmHg at 25℃

 

Safety Information:

Safety Statements: S26; S36

HS Code: 2933990090

Risk Statements: R36/37/38

Hazard Codes: Xi,Xn

Hazard Declaration: H302

Signal Word: Warning

Symbol: GHS07

WGK Germany: 3

 

Valacyclovir hydrochloride is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. Target: HSVValacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. VACV uptake was concentration dependent and saturable with a Michaelis-Menten constant and maximum velocity of 1.64 +/- 0.06 mM and 23.34 +/- 0.36 nmol/mg protein/5 min, respectively. A very similar Km value was obtained in hPEPT1/CHO cells and in rat and rabbit tissues and Caco-2 cells, suggesting that hPEPT1 dominates the intestinal transport properties of VACV in vitro . For treatment of a first episode of genital herpes, a large comparative trial has shown that valacyclovir (1 g twice a day) is as effective as acyclovir (200 mg five times a day) when given for 10 days. For treating recurrences, two trials show that valacyclovir is as effective as acyclovir (200 mg five times a day) with a treatment period of 5 days. A daily dose of 1 g of valacyclovir is as effective as 2 g daily. Valacyclovir can be administered once a day. The concentrations of acyclovir in serum and CSF were measured at steady state after 6 days of oral treatment with 1,000 mg of valacyclovir three times a day. EC50 values of PE and AC in 3T3 cells were 0.02 and 0.01 ug/ml, while values in BHK cells were 0.2 and 0.03 ug/ml. Treatment of infected immunosuppressed mice and FA and VA (b.i.d., 5.5 days) reduced the proportion with erythema from 100% to 24% and 38%, and eliminated ear paralysis, ear lesions (vesicles, etc) and death. Virus was absent from ear and brainstem by day 6, but reappeared after discontinuation in mice treated with VA.

 

If you are interested in our products or have any questions, please feel free to contact us!

 

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

 

Related Products:4-Methyl-2-Phenyl-1H-Imidazole-5-Methanol manufacturer | (R)-α-METHYL-PHENYLGLYCINAMIDE supplier | [2-(4-fluorophenyl)-1,3-oxazol-4-yl]methanamine producer.