Tetrahydrozoline Hydrochloride

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Tetrahydrozoline Hydrochloride
2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole,hydrochloride
 
Appearance and properties: off-white solid
Boiling point: 393.5ºC at 760 mmHg
Melting point: 197 °C
Flash point: 191.8ºC
 
Storage conditions: Refrigerator
Uses: Tetrahydrozoline hydrochloride is an α-adrenergic receptor agonist.
 

Items of Analysis Standard of Analysis Test Results
Appearance White to off-white powder Conforms
Identification IR spectrum
UV spectrum
Reaction of Chlorides
Conforms
Conforms
Positive
Heavy metals(USP) NMT 0.005% <0.005%
Loss on drying(USP) NMT 1.0% 0.2%
Residue on ignition NMT 0.1% <0.1%
Related substances-sum:
 -TLC(USP)
-HPLC
NMT 2.0%
NMT 1.0%
<2.0%
0.8%
Assay(in the dried substance):
 -titration(USP)
98.0-100.5% 99.7%
Residual solvents:
-Methanol
-Ethanol
-Acetonitrile
-Toluene
NMT 3000ppm
NMT 5000ppm
NMT 410ppm
NMT 890ppm
Not detected
Conforms
Not detected
Not detected
Conclusion Conforms to USP 39
 

Tetrahydrozoline Hydrochloride


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