terbinafine hydrochloride

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terbinafine hydrochloride
Terbinafine hydrochloride
(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine monohydrochloride
 
Appearance and properties: crystalline powder
Density: 1.007g/cm3
Boiling point: 417.9ºC at 760 mmHg
Melting point: 204-208°C
Flash point: 183.7ºC
Refractive index: 1.586
 
Storage conditions: -20ºC Freezer
Use:
It is an antifungal drug for the treatment of fungal infections. It is an effective non-competitive inhibitor of squalene epoxidase from Candida with a Ki value of 30 nM.
 
 

Items of Analysis Standard of Analysis Test Results
Appearance White or off-white powder Off-white powder
Identity by 1H-NMR
(Solvent: Chloroform-d)
Reference to original data Conform
Purity by HPLC
 (Area nominalization)
≥94.0% (A) 94.15%
Melting Point For information 200.2~200.6 ℃
Loss on drying ≤0.50% (w/w) 0.46%
Conclusion Conforms to Factory Standard
 

terbinafine hydrochloride


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