terbinafine hydrochloride

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terbinafine hydrochloride
Terbinafine hydrochloride
(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine monohydrochloride
 
Appearance and properties: crystalline powder
Density: 1.007g/cm3
Boiling point: 417.9ºC at 760 mmHg
Melting point: 204-208°C
Flash point: 183.7ºC
Refractive index: 1.586
 
Storage conditions: -20ºC Freezer
Use:
It is an antifungal drug for the treatment of fungal infections. It is an effective non-competitive inhibitor of squalene epoxidase from Candida with a Ki value of 30 nM.
 
 

Items of Analysis	Standard of Analysis	Test Results
Appearance	White or off-white powder	Off-white powder
Identity by 1H-NMR (Solvent: Chloroform-d)	Reference to original data	Conform
Purity by HPLC  (Area nominalization)	≥94.0% (A)	94.15%
Melting Point	For information	200.2~200.6 ℃
Loss on drying	≤0.50% (w/w)	0.46%
Conclusion	Conforms to Factory Standard

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