Rolapitant Cas:552292-08-7

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Product Description:

Product Name: Rolapitant CAS NO: 552292-08-7

 

Synonyms:

Sch 619734 free base;

(5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one;

 

Chemical & Physical Properties:

Appearance: Powder or liquid

Assay :≥99.00%

Density: 1.34±0.1 g/cm3(Predicted)

Boiling Point: 523.5±50.0℃(Predicted)

Pka: 15.88±0.40(Predicted)

Flash Point: 270.4±30.1℃

Vapour Pressure: 0.0±1.4 mmHg at 25℃

Index of Refraction: 1.542

 

An azaspiro compound that is 1,7-diazaspiro[4.5]decan-2-one carrying additional phenyl and 1-{[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl substituents at position 8. Used (in the form of the hydrochloride hydrate) for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.

 

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