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Product Description:
Product Name: Ribociclib CAS NO: 1211441-98-3
Synonyms:
7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;
LEE 011;
Chemical & Physical Properties:
Appearance: White to off-white powder
Assay :≥99.0%
Density:1.39g/cm3
Boiling Point:730.8℃ at 760 mmHg
Flash Point:395.8℃
Solubility: Soluble in DMSO, not soluble in water.
Description: Ribociclib Free Base, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
Related CAS#
1211441-98-3 (Ribociclib free base)
1211443-80-9 (Ribociclib hydrochloride)
1374639-75-4 (Ribociclib succinate)
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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.
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