Retinoic Acid Cas:302-79-4

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Retinoic Acid

Product Description:

Product Name: Retinoic acid CAS NO: 302-79-4

 

Synonyms:             

(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid;

all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid;

Vitamin A Acid;

 

Chemical & Physical Properties:

Appearance: Yellow-orange powder

Assay :≥99.0%

Density: 1.011 g/cm3

Boiling Point: 462.8℃ at 760 mmHg

Melting Point: 179-184℃

Flash Point: 350.6℃

Sensitive: Light Sensitive

 

Safety Information:

Safety Statements: S36/37-S45

HS Code: 2916209090

Risk Statements: R22; R38; R63

Hazard Code: Xn

Caution Statements: P301 + P312 + P330

Signal Word: Warning

Symbol: GHS07

Hazard Declaration: H302

 

Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. Retinoic acid is required in chordate animals, which includes all higher animals from fish to humans. During early embryonic development, retinoic acid generated in a specific region of the embryo helps determine position along the embryonic anterior/posterior axis by serving as an intercellular signaling molecule that guides development of the posterior portion of the embryo. It acts through Hox genes, which ultimately control anterior/posterior patterning in early developmental stages.

The key role of retinoic acid in embryonic development mediates the high teratogenicity of retinoid pharmaceuticals, such as isotretinoin used for treatment of cancer and acne. Oral megadoses of pre-formed vitamin A (retinyl palmitate), and retinoic acid itself, also have teratogenic potential by this same mechanism.

 

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