(R)-1-(3,5-Bis-Trifluoromethyl-Phenyl)-Ethanol

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CAS No: 127852-28-2
Product Name: (R)-1-(3,5-Bis-Trifluoromethyl-Phenyl)-Ethanol
Other Name:
(R)-1-(3,5-Bis-Trifluoromethyl-Phenyl)-Ethanol
(R)-3,5-Bis(trifluoromethyl)-α-methylbenzyl Alcohol
(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl Alcohol
 
Density: 1.4±0.1 g/cm3
Boiling Point: 175.8±35.0 °C at 760 mmHg
Molecular Formula: C10H8F6O
Molecular Weight: 258.160
Flash Point: 60.1±25.9 °C
Exact Mass: 258.047943
PSA: 20.23000
LogP: 2.81
Vapour Pressure: 0.7±0.4 mmHg at 25°C
Index of Refraction: 1.418
 
Specification
Appearance: White to off white powder
MP: 50℃-54℃
Optical rotation: +19℃- +25℃
Assay: ≥99.0%
Water: ≤0.5%
Single impurity: ≤0.5%
 
Application
Intermediates of Fosaprepitant CAS: 172673-20-0.
Intermediates of Aprepitant CAS: 170729-80-3.
Be used as pharmaceutical intermediate.
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
 
Package: 25kg/drum, can also be designed according to customer requirements.
Storage: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

(R)-1-(3,5-Bis-Trifluoromethyl-Phenyl)-Ethanol


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