Chemicals

(R)-1-(3,5-Bis-Trifluoromethyl-Phenyl)-Ethanol

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CAS No: 127852-28-2

Product Name: (R)-1-(3,5-Bis-Trifluoromethyl-Phenyl)-Ethanol

Other Name:

(R)-3,5-Bis(trifluoromethyl)-α-methylbenzyl Alcohol

(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl Alcohol

Density: 1.4±0.1 g/cm3

Boiling Point: 175.8±35.0 °C at 760 mmHg

Molecular Formula: C10H8F6O

Molecular Weight: 258.160

Flash Point: 60.1±25.9 °C

Exact Mass: 258.047943

PSA: 20.23000

LogP: 2.81

Vapour Pressure: 0.7±0.4 mmHg at 25°C

Index of Refraction: 1.418

Specification

Appearance: White to off white powder

MP: 50℃-54℃

Optical rotation: +19℃- +25℃

Assay: ≥99.0%

Water: ≤0.5%

Single impurity: ≤0.5%

Application

Intermediates of Fosaprepitant CAS: 172673-20-0.

Intermediates of Aprepitant CAS: 170729-80-3.

Be used as pharmaceutical intermediate.

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

Package: 25kg/drum, can also be designed according to customer requirements.

Storage: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

(R)-1-(3,5-Bis-Trifluoromethyl-Phenyl)-Ethanol

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