Quinine Cas:130-95-0

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Product Description:

Product Name: Quinine CAS NO: 130-95-0

 

Synonyms:             

(R)-(6-Methoxyquinolin-4-yl)((1R,2R,4R,5S)-5-vinylquinuclidin-2-yl)Methanol;

(1R)-(6-Methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)Methanol;

(R)-[(2S,4S,5R)-1-Aza-5-vinylbicyclo[2.2.2]oct-2-yl](6-methoxyquinolin-4-yl)methanol;

 

Chemical & Physical Properties:

Appearance: White Crystalline Powder

Assay :≥99.0%

Density: 1.21g/cm3

Boiling Point: 495.9℃ at 760mmHg

Melting Point: 176-177℃

Flash Point: 253.7℃

Refractive Index: 1.625 (15℃)

Stability: Stable under normal temperatures and pressures. May discolor on exposure to light.

Storage Condition: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40℃.

Vapor Pressure: 0mmHg at 25℃

 

Safety Information:

Hazard Class: 6.1(b)

Safety Statements: S26-S37/39

HS Code: 29392110

Packing Group: III

WGK Germany: 3

RIDADR: UN 1544

Risk Statements: R22; R36/37/38

Hazard Code: Xn

 

Quinine is one of the oldest antimalarial drugs. At as early as the 15th century, the quinine-containing cinchona bark has been used extensively in the treatment of malaria with its antimalarial effect being similar to that of chloroquine that is through interfering with DNA synthesis effect. It is capable of inhibiting the erythrocytic stage of a variety of Plasmodium, being able to control the malaria symptoms. It also has certain killing effect on the gametes of vivax malaria and quartan malaria. However, it has no effect on the exoerythrocytic stage. Its major advantage is not easy to produce drug resistance, possibly due to that quinine binds the plasmodium DNA in a different way from chloroquine, so having no cross-resistance and can be used for the treatment of the infection of anti-chloroquine strains (especially Plasmodium falciparum). In addition, quinine can also exciting the uterus, inhibit the myocardium and have antipyretic analgesic effect. In addition to medicinal application, in analytical chemistry it can be used as the detection agent of bismuth, platinum and other metal ions and also be used for the separation agent of racemic organic acid.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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