Pyrazinamide Cas:98-96-4

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Product Description:

Product Name: Pyrazinamide CAS NO: 98-96-4

 

Synonyms:             

Aldinamid;

pyrazine-2-carboxylic acid amide;

Zinamide;

 

Chemical & Physical Properties:

Appearance: Clear to off-white crystalline powder

Assay :≥99.0%

Density: 1.301g/cm3

Boiling Point: 357.4℃ at 760 mmHg

Melting Point: 188-191℃

Flash Point: 169.9℃

Water Solubility: 15 mg/mL

Stability: Stable under normal temperatures and pressures.

Storage Condition: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40℃.

 

Safety Information:

RTECS: UQ2275000

Safety Statements: S24/25

HS Code: 2933599090

WGK Germany: 3

Risk Statement: R11

Hazard Codes: F; C

 

Pyrazinamide is a drug used to treat tuberculosis. The drug is largely bacteriostatic, but can be bacteriocidal on actively replicating tuberculosis bacteria.

It is on the World Health Organization”s List of Essential Medicines, the most important medications needed in a basic health system. Pyrazinamide is a pyrazine that is used therapeutically as an antitubercular agent.Target: AntibacterialPyrazinamide is a prodrug that stops the growth of Mycobacterium tuberculosis. Pyrazinoic acid was thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids although this has been discounted. It was also suggested that the accumulation of pyrazinoic acid disrupts membrane potential and interferes with energy production, necessary for survival of M. tuberculosis at an acidic site of infection. Pyrazinoic acid binds to the ribosomal protein S1 (RpsA) and inhibits trans-translation. This may explain the ability of the drug to kill dormant mycobacteria.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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