Prazosin Hydrochloride Cas:19237-84-4

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Prazosin Hydrochloride

Product Description:

Product Name: Prazosin hydrochloride CAS NO: 19237-84-4

 

Synonyms:

[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone,hydrochloride;

6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-piperazinyl]quinazoline hydrochloride;

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine Hydrochloride;

 

Chemical & Physical Properties:

Appearance: Off-white to yellow powder

Assay :≥99.00%

Boiling Point: 638.4℃ at 760 mmHg

Melting Point: 277 – 280℃

Flash Point: 339.9℃

Vapor Pressure: 3.4E-16mmHg at 25℃

Water Solubility: Soluble in dimethyl sulfoxide, ethanol, water, methanol.

 

Safety Information:

RTECS: VA1350000

Hazard Class: 6.1(b)

Safety Statements: S28-S36

WGK Germany: 3

Packing Group: III

RIDADR: UN 3249

Risk Statements: R22; R36/37/38; R62

Hazard Code: Xn

Hazard Declaration: H302; H315; H319; H335; H361

Caution Statements: P261; P281; P305 + P351 + P338

Signal Word: Warning

Symbols: GHS07, GHS08

 

An antihypertensive. α1-Adrenergic blocker. Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.Target: Adrenergic ReceptorPrazosin, is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. It is an alpha-adrenergic blocker that is specific for the alpha-1 receptors. These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine. They are also found throughout the central nervous system. As of 2013, prazosin is off-patent in the US, and the FDA has approved at least one generic manufacturer.In addition to its alpha-blocking activity, prazosin is an antagonist of the MT3 receptor (which is not present in humans), with selectivity for this receptor over the MT1 and MT2 receptors. Prazosin is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. However, when prazosin is initially started, heart rate and contractility go up in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure. The blood pressure lowering effect becomes apparent when prazosin is taken for longer periods of time. The heart rate and contractility go back down over time and blood pressure decreases.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.



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