Praziquantel Cas:55268-74-1

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Product Description:

Product Name: Praziquantel CAS NO: 55268-74-1

 

Synonyms:

1-a]-isoquinolin-4-one,2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2;

2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4;

4h-pyrazino(2,1-a)isoquinolin-4-one,2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexah;

 

Chemical & Physical Properties:

Appearance: White or practically white crystalline powder

Assay :≥99.00%

Density: 1.22 g/cm3

Boiling Point: 544.1℃at 760 mmHg

Melting Point: 136-142℃

Flash Point: 254.6℃

Stability: Stable at normal temperatures and pressures.

Storage Condition: -20℃

 

Safety Information:

RTECS: UQ4150000

Safety Statements: S16; S26; S36/37/39; S45

HS Code: 2933790090

WGK Germany: 1

Risk Statement: R11

Hazard Codes: F; C

 

Praziquantel, marketed as Biltricide, is an anthelmintic used for the treatment of tapeworms and flukes. For example, it is effective against Schistosoma (blood flukes), the liver fluke Clonorchis sinensis and the fish tapeworm Diphyllobothrium latum.It is on the World Health Organization”s List of Essential Medicines, the most important medications needed in a basic health system. Praziquantel is an anthelmintic effective against flatworms.Target: AntiparasiticPraziquantel is the drug of choice for treatment of all human schistosomes. Infected mice were treated with increasing Praziquantel doses until the highest dose of 3 × 300 mg/Kg was reached. The effect of Praziquantel treatment on the parasite population was assessed using five polymorphic microsatellite markers. Parasitological and genetic data were compared with those of the untreated control. After six parasite generations submitted to treatment, it was possible to obtain a S. mansoni population with decreased susceptibility to Praziquantel. In our experiments we also observed that female worms were more susceptible to Praziquantel than male worms.

 

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