Pomalidomide Cas:19171-19-8

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Product Description:

Product Name: Pomalidomide CAS NO: 19171-19-8

 

Synonyms:

1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-;

4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;

3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide;

 

Chemical & Physical Properties:

Appearance: Yellow powder

Assay :≥99.00%

Density: 1.57g/cm3

Boiling Point: 582.9℃ at 760mmHg

Flash Point: 306.3℃

Refractive Index: 1.691

Vapor Pressure: 1.41E-13mmHg at 25℃

Storage condition: 2-8℃

Water Solubility: DMSO: ≥14mg/mL

 

Safety Information:

HS Code: 2925190090

WGK Germany: 3

RTECS: NR3397905

 

Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma. Pomalidomide is an immuno-modulator drug (IMID) developed by Celgene, Inc. in the United States. It is a synthetic drug modified on the basis of the chemical structure of the first generation IMID, which was developed by Celgene. It can enhance the immune response mediated by T cells and natural killer cells, inhibit the generation of pro-inflammatory cytokines in monocytes, and induce tumor cell apoptosis. It has been widely concerned in the treatment of various malignant tumors and immune diseases. Pomadomide, chemically named 4-amino-2 – (2, 6-dioxy-piperidine-3-yl) -isodihydroindole-1, 3-dione, is a thalidomide analogram and an immunomodulator with anti-tumor activity. Chemicalbook can inhibit the proliferation and induce apoptosis of hematopoietic tumor cells in in vitro cytology tests. In addition, pomadomide inhibited the proliferation of lenalidomine-resistant multiple myeloma cell lines and induced apoptosis of tumor cells in lenalidomine-sensitive and lenalidomine-resistant cell lines in collaboration with dexamethasone.

 

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