Penfluridol Cas:26864-56-2

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Product Description:

Product Name: Penfluridol CAS NO: 26864-56-2

 

Synonyms:

1-[4,4-Bis(p-fluorophenyl)butyl]-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-piperidinol;

4-Piperidinol, 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-;

4-Piperidinol, 4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-1-(4,4-bis(p-fluorophenyl)butyl)-;

 

Chemical & Physical Properties:

Appearance: Off-white to white crystalline powder

Assay :≥99.0%

Density: 1.29 g/cm3

Boiling Point: 587.7℃ at 760 mmHg

Melting Point: 105-107℃

Flash Point: 309.2℃

Refractive Index: 1.552

Stability: Stable at normal temperatures and pressures.

Storage Condition: 2-8℃

Vapor Pressure: 1.17E-14mmHg at 25℃

 

Safety Information:

RTECS: TN6957000

Hazard Class: 6.1

Safety Statement: S45

HS Code: 2942000000

WGK Germany: 3

RIDADR: UN 2811

Risk Statement: R25

Hazard Code: T

Hazard Declaration: H301

Symbol: GHS06

Signal Word: Danger

Caution Statement: P301 + P310

 

Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects last for many days after single oral dose. Its antipsychotic potency, in terms of dose needed to produce comparable effects, is similar to both haloperidol and pimozide. It is only slightly sedative, but often causes extrapyramidal side-effects, such as akathisia, dyskinesiae and pseudo-Parkinsonism. Penfluridol is indicated for antipsychotic treatment of chronic schizophrenia and similar psychotic disorders, it is, however, like most typical antipsychotics, being increasingly replaced by the atypical antipsychotics. Due to its extremely long-lasting effects, it is often prescribed to be taken orally as tablets only once a week (q 7 days). The once-weekly dose is usually 10–60mg.

 

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