ORM-15341 Cas:1297537-33-7

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Product Description:

Product Name: ORM-15341 CAS NO: 1297537-33-7







Chemical & Physical Properties:

Appearance: Powder

Assay :≥99.00%

Boiling Point: 714.7±60.0℃(Predicted)

Density: 1.41±0.1 g/cm3(Predicted)

Pka: 8.70±0.10(Predicted)

Solubility: DMSO: > 37 mg/mL

Storage: -20℃ Freeze


ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.IC50 value: 38 nMTarget: androgen receptorin vitro: In competitive AR binding assays, the inhibition constant (Ki) values of ORM-15341 was 8 nM. ORM-15341 functions as a full antagonist for all tested mutant ARs , with IC50 of 25, 51, 700, and 1160 nM for wtAR, AR(F876L), AR(T877A), and AR(W741L).


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