O-3,4,5-trifluorophenyl carbonochloridothioate Cas:959586-39-1

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O-3,4,5-trifluorophenyl carbonochloridothioate

Chemical Name:O-3,4,5-trifluorophenyl carbonochloridothioate
CAS.NO:959586-39-1
Synonyms:O-3,4,5-trifluorophenyl carbonochloridothioate
 
Physical and Chemical Properties:
Density 1.590±0.06 g/cm3(
Boiling Point 212.4±35.0 °C
Molecular Formula C7H2ClF3OS
Molecular Weight 226.6033896
 
Description:
Appearance:Orange-red liquid or solid
Assay:≥93.0%
 
Packing:200 kg/drum, can also be packaged according to customer requirements
Storage:Store in a cool, ventilated place
Use:Intermediate of Organic synthesis.



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TIGIT is highly expressed in gastric cancer. And pre-clinical experiments have proved that synergistically targeting PD-1 and TIGIT could significantly repress gastric tumor growth. We look forward to the clinical results of IBI321, particularly in GI tumors.
Dr. Hui Zhou, Senior Vice President of Clinical Development of Innovent, stated: “By specifically targeting both PD-1 and TIGIT, this type of bispecific antibody is designed to provide synergistic effects by blocking both the PD-1/PD-L1 and TIGIT/CD155 pathways – with the goal of improving the anti-cancer efficacy.
Currently, there is no bispecific antibody that has same target as IBI321 in clinical-stage development worldwide. Preclinical studies of IBI321 have demonstrated that the combination of these two monoclonal antibodies further enhanced the immune activation with improved convenience of administration.
Therefore, the development of an anti-PD-1/TIGIT bispecific antibody has the potential to provide patients with more effective and convenient treatment. We look forward to hope that IBI321 will benefit more patients. apraclonidine hydrochloride supplier And finally, CHMP also concluded its investigation into bluebird bio’s Zynteglo, finding no evidence that it causes a blood cancer known as acute myeloid leukemia. O-isopropyl ethylthiocarbamate producer

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