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Product Name: Norethindrone CAS NO: 68-22-4
Chemical & Physical Properties:
Appearance: Off-White to Pale Yellow Solid
Density: 1.15 g/cm3
Boiling Point: 447℃ at 760 mmHg
Melting Point: 205-206℃
Refractive Index: 1.577
Storage Condition: -20℃ Freezer
Safety Statements: S22; S36/37/39; S45; S26
HS Code: 2937290090
WGK Germany: 3
Risk Statement: R40
Hazard Code: Xn
Hazard Declaration: H351
Signal Word: Warning
Norethisterone (INN, BAN), also known as norethindrone (USAN), as well as 19-nor-17α-ethynyltestosterone, but more commonly known under its trade name Utovlan®, is a steroidal progestin used in some combined oral contraceptive pills and progestogen-only pills, and also available as a standalone drug. It can be used to treat premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, menopausal syndrome (in combination with estrogen), or to postpone a period. It is also commonly used to help prevent uterine hemorrhage in complicated non-surgical or pre-surgical gynecologic cases and in treating non responsive cyclical mastalgia. Norethisterone was the first orally highly active progestin to be synthesized.
It was synthesized for the first time by chemists Luis Miramontes, Carl Djerassi, and George Rosenkranz at Syntex in Mexico City in 1951. It was the progestin used in one of the first three oral contraceptives. Its related ester, norethisterone acetate, is used for the same indications. Norethisterone was first introduced, as Norlutin, in 1957.
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