N,O-Bis(trimethylsilyl)acetamide

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Chemical Name:N,O-Bis(trimethylsilyl)acetamide
CAS.NO:10416-59-8
Synonyms:BSA
Molecular Formula:C8H21NOSi2
Molecular Weight:203.42900
 
Physical and Chemical Properties:
Density:0.832;
Melting point:24oC;
Boiling point:71-73oC;
Flash point:42oC;
Index of Refraction:1.417;
 
Specification:
Appearance:Clear to yellowish clear liquid
Purity(GC):≥98.0%
 
Packing:25 kg/drum, can also be packaged according to customer requirements
Storage:Store in a cool, ventilated place
Application:The trimethylsilyl group is a frequently utlized monofunctional blocking group for protic organic and inorganic materials.
As the product eliminated during the silylation is neutral acetamide, it can be preferably used for substrates which are acid-or base-sensitive.
It can be used for blocking and protection of hydroxyl groups in natural products,e.g. amino acids, carbohydrates.
It can be used for blocking and protection of functional groups in organic intermediates.
The silylated derivatives show improved chemical stability than the original compounds and allow chemical reactions which otherwise would not be possible.
It can be used for formation of derivatives of H-acid compounds for analysis.
The silylated derivatives are volatile and can therefore be determined by gas chromatography.

N,O-Bis(trimethylsilyl)acetamide


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