Nizatidine Cas:76963-41-2

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Product Description:

Product Name: Nizatidine CAS NO: 76963-41-2

 

Synonyms:

N-[2[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-N”-methyl-2-nitro-1,1-ethenediamine;

(E)-1-N”-[2-[[2-[(dimethylamino)methyl]-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;

Galitidin;

 

Chemical & Physical Properties:

Appearance: White to off-white crystalline powder

Assay :≥99.00%

Density: 1.249g/cm3

Melting Point: 130-132℃

Refractive Index: 1.592

Storage Condition: -20℃ Freezer

Solubility: Sparingly soluble in water, soluble in methanol.

Water Solubility: 21.4g/L(temperature not stated)

 

Safety Information:

Safety Statement: S36

HS Code: 2934999090

Risk Statement: R22

Hazard Code: Xn

WGK Germany: 3

RTECS: KM6565000

 

Nizatidine is a histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion.Target: Histamine H2 ReceptorNizatidine, a selective histamine H2-receptor antagonist, is a potent inhibitor of gastric acid secretion, with IC50 of 0.9 nM. Nizatidine exhibits maximal inhibition of gastric acid in rats within the first hour of drug administration, with EC50 of 1.383 μmol/kg. Nizatidine also reversibly inhibits acetylcholinesterase (AChE), with IC50 of 6.7 μM, and the inhibition is noncompetitive, with a Ki value of 7.4 μM. Nizatidine (0.3-3 mg/kg, i.v.) significantly increases the motor index of gastrointestinal (GI) motility in a dose-dependent manner. Nizatidine inhibits gastric acid secretion with ED50 and ED90 of 0.18 and 3.22 mg/kg in dogs, and 2.94 and 19.6 mg/kg in rats, respectively .

 

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