N2′-Deacetyl-N2′-(4-mercapto-4-methyl-1-oxopentyl)-maytansine(DM4) Cas:796073-69-3

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Product Description:

Product Name: N2”-Deacetyl-N2”-(4-mercapto-4-methyl-1-oxopentyl)-maytansine(DM4) CAS NO: 796073-69-3

 

Synonyms:

Maytansine, N2”-deacetyl-N2”-(4-mercapto-4-methyl-1-oxopentyl)-;DM4 top3;

Mertansine Impurity 1;

N2”-Deacetyl-N2”-(4-mercapto-4-methyl-1-oxopentyl)-maytansine(DM4);

 

Chemical & Physical Properties:

Appearance: Powder

Assay :≥99.0%

Density: 1.29±0.1 g/cm3(Predicted)

Melting Point: 185-187 ℃ (decomp)

Boiling Point: 943.2±65.0℃(Predicted)

Pka: 9.82±0.70(Predicted)

 

Ravtansine (DM4) is a maytansinoid, a chemical derivative of maytansine being investigated as the cytotoxic payload of a number of antibody-drug conjugates (ADCs).M4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate.

N2””-Deacetyl-N2””-(4-mercapto-4-methyl-1-oxopentyl)-maytansine is an intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for the targeted treatment of cancer.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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