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Product Description:
Product Name: Midostaurin CAS NO: 120685-11-2
Synonyms:
4”-N-benzoylstaurosporine;
PKC412,[9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3”,2”,1”-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide;
Cgp 41 251;
Chemical & Physical Properties:
Appearance: Tan solid
Assay :≥99.0%
Density: 1.46g/cm3
Refractive Index: 1.76
Storage Condition: Store at 2-8℃
Solubility: Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100% ethanol (2.5 mg/ml), and DMF (20 mg/ml).
Safety Information:
Hazard Code: T
Risk Statements: R36/37/38
HS Code: 29329990
Midostaurin (PKC412) is a multi-target protein kinase inhibitor being investigated for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). It is a semi-synthetic derivative of staurosporine, an alkaloid from the bacterium Streptomyces staurosporeus, and is active in patients with mutations of CD135 (FMS-like tyrosine kinase 3 receptor, FLT3).
After successful Phase II clinical trials, a Phase III trial for AML has started in 2008. It is testing midostaurin in combination with daunorubicin and cytarabine. In another trial, the substance has proven ineffective in metastatic melanoma.
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