Midostaurin Cas:120685-11-2

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Midostaurin

Product Description:

Product Name: Midostaurin CAS NO: 120685-11-2

 

Synonyms:

4”-N-benzoylstaurosporine;

PKC412,[9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3”,2”,1”-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide;

Cgp 41 251;

 

Chemical & Physical Properties:

Appearance: Tan solid

Assay :≥99.0%

Density: 1.46g/cm3

Refractive Index: 1.76

Storage Condition: Store at 2-8℃

Solubility: Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100% ethanol (2.5 mg/ml), and DMF (20 mg/ml).

 

Safety Information:

Hazard Code: T

Risk Statements: R36/37/38

HS Code: 29329990

 

Midostaurin (PKC412) is a multi-target protein kinase inhibitor being investigated for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). It is a semi-synthetic derivative of staurosporine, an alkaloid from the bacterium Streptomyces staurosporeus, and is active in patients with mutations of CD135 (FMS-like tyrosine kinase 3 receptor, FLT3).

After successful Phase II clinical trials, a Phase III trial for AML has started in 2008. It is testing midostaurin in combination with daunorubicin and cytarabine. In another trial, the substance has proven ineffective in metastatic melanoma.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.



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