Meprednisone Hemisuccinate Cas:27303-92-0

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Product Description:

Product Name: Meprednisone hemisuccinate CAS NO: 27303-92-0

 

Synonyms:

X1048;

I06-2400;

4-[2-[(8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-10,13,16-trimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid;

 

Chemical & Physical Properties:

Appearance: Solid

Assay :≥99.0%

Density: 1.33

Boiling Point: 692.3℃ at 760 mmHg

Refractive Index: 1.587

Vapor Pressure: 3.54E-22mmHg at 25℃

 

Methylprednisolone is a medium – potency glucocorticoid. The effect is the same as prednisolone, its anti-inflammatory effect is 3 times of the latter, sugar metabolism is 10 times stronger than hydrocortisone, and water and sodium retention is weak, no side effects of potassium discharge. Methylprednisolone acetate suspension can be decomposed and absorbed slowly and maintained for a long time by intramuscular injection or intraluminal injection. The average peak concentration of methylprednisolone acetate suspension is 14.8μg/L after 6-8 hours of intramuscular injection, which can be maintained for 11-17 days. Its sodium succinate is water-soluble, can be intramuscular or intravenous drip. The oral bioavailability was 82%, the plasma protein binding rate was 40% ~ 60%, and the half-life was about 2.5 hours. Methylprednisone semi-succinate is an ester formed by methylprednisone and succinic acid.

 

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