Luliconazole Cas:187164-19-8

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Product Description:

Product Name: Luliconazole CAS NO: 187164-19-8

 

Synonyms:

(2E)-2-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile;

4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene-1-imidazolylacetonitrile;

1H-Imidazole-1-acetonitrile,a-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-,(aE)-;

 

Chemical & Physical Properties:

Appearance: White solid

Assay :≥99.00%

Density: 1.52g/cm3

Boiling Point: 499.1℃ at 760mmHg

Flash Point: 255.6℃

Refractive Index: 1.734

Vapor Pressure: 4.27E-10mmHg at 25℃

 

Safety Information:

Hazard Declaration: H315; H319

Symbol: GHS07

Caution Statements: P305 + P351 + P338

Signal Word: Warning

 

Luliconazole is an azole antifungal drug. Luliconazole(NND 502) is an azole antifungal indicated for the topical treatment of interdigital tinea pedis.IC50 Value: Target: AntifungalLuliconazole is an antifungal that belongs to the azole class. Although the exact mechanism of action against dermatophytes is unknown, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase. Inhibition of this enzyme’s activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol. In a fertility study in rats, subcutaneous doses of 1, 5 and 25 mg/kg/day luliconazole were administered prior to and during mating and through early pregnancy. Treatment related effects on reproductive function were noted in females (decreased live embryos and decreased corpus luteum) at 5 and 25 mg/kg/day and males (decreased sperm counts) at 25 mg/kg/day. No treatment related effects on fertility or reproductive function were noted at 1 mg/kg/day (0.1X MRHD based on BSA comparisons).

 

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