ketorolac tromethamine Cas:74103-07-4

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ketorolac tromethamine

Synonyms:
ketorolac tromethamine
2-amino-2-(hydroxymethyl)propane-1,3-diol,5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
rac Ketorolac Tromethamine Salt

 
molecular formula: C19H24N2O6
Molecular weight: 376.40400
 
Physical Properties:
Appearance and Properties: Crystalline
Boiling point: 493.2ºC at 760 mmHg
Melting point: 160-161ºC
Flash point: 252.1ºC

 
Specification:
Test Acceptance Criteria Results
 
Appearance
 
a white or almost white,
crystalline powder.
An almost white crystalline powder.
 
PH 5.7~6.7 5.9
Related substances 1-ketone-ketorolac acid ≤ 0. 1%
1- hydroxyl-ketorolac acid ≤0. 1%;
other single impurity≤ 0.5%;
0.0030%
not detected
conforms
total impurities ≤ 1.0% 0. 19%
Loss on drying ≤0.5% 0. 05%
Residue on ignition ≤0. 1% 0.03%
Heavy Metals ≤0.002% Conforms
Assay on the dried basis ≥98.5% 99.4%
Microorganism limits Bacteria amount:          ≤ 1000/g
Mould and microzyme amount:       ≤ 100/g
Colibacillus:should be not detected
Acarid :  should be not detected
<10/g
<10/g not
detected
not detected
 

 
Application:
Ketorolac tromethamine salt is a non-steroidal anti-inflammatory agent and a non-selective COX inhibitor with IC50 values of 20 nM and 120 nM for COX-1 and COX-2, respectively.
 
Package and Storage:
1kg/bottle or bag
25kgs/drum or bag
 
 



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