Isoniazide Cas:54-85-3

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Isoniazide

Synonyms:
4-pyridinecarbohydrazide
isonicotinoyl hydrazide
Isoniazid
isonicotinic acid hydrazid
4-pyridine-carbonic acid hydrazide
pyridine-4-carboxylic acid hydrazide
4-Pyridinecarboxylic acid, hydrazide
 
Molecular Formula: C6H7N3O
Molecular weight:137.13900

Appearance and properties: white crystalline powder
Density: 1.244g/cm3
Melting point: 171-173 °C(lit.)
Flash point: >250°C
Refractive index: 1.5502 (18ºC)
Water solubility: 14 g/100 mL (25 ºC)
 
Stability: Stability Stable, but may be air or light sensitive. Combustible. Incompatible with strong oxidizing agents, chloral, aldehydes, iodine, ferric salts, hypochlorites.
Storage conditions: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Uses: Isoniazid is an antibiotic with anti-tuberculosis effect.
 

Items of Analysis Standard of Analysis Test Results
Appearance White or almost white crystalline powder Conform
Solubility Freely soluble in water, sparingly soluble in alcohol Conform
Identification A-Melting Point: 170-174℃
B-IR: As per BP
171.5-172.5℃
Positive
pH 6.0-8.0 7.1
Appearance of solution Solution S is clear and not more intensely colored than reference solution BY7 Conforms to RSBY7
Heavy metals ≤10ppm <10ppm
Hydrazine & Related Substances Any secondary spot: ≤0.2%
Hydrazine spot: ≤0.05%
<2%
<0.05%
Loss on drying ≤0.50% 0.12%
Sulphated ash ≤0.1% 0.05%
Assay 99.0%-101.0% 99.7%
Conclusion Conforms to BP2015 standard
 

 
 
 



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