Inosine Cas:58-63-9

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Product Description:

Product Name: Inosine CAS NO: 58-63-9

 

Synonyms:

beta-Inosine;

beta-D-Ribofuranoside, hypoxanthine-9;

Hypoxanthine D-riboside;

 

Chemical & Physical Properties:

Appearance: White powder

Assay :≥99.0%

Density: 2.08 g/cm3

Boiling Point: 732.8℃ at 760 mmHg

Melting Point: 212-213℃

Flash Point: 397℃

Refractive Index: -52 ° (C=1, H2O)

Water Solubility: 2.1 g/100 mL (20℃)

Vapor Pressure: 0.0±2.2 mmHg at 25℃

Stability: Stable under normal temperatures and pressures

Storage Condition: Store at RT

 

Safety Information:

Hazard Code: Xi

HS Code: 2934999090

WGK Germany: 2

RTECS: NM7460000

Risk Statements: R36/37/38

Safety Statements: S24/25

 

Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond.

Inosine is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs.

Knowledge of inosine metabolism has led to advances in immunotherapy in recent decades. Inosine monophosphate is oxidised by the enzyme inosine monophosphate dehydrogenase, yielding xanthosine monophosphate, a key precursor in purine metabolism. Mycophenolate mofetil is an anti-metabolite, anti-proliferative drug that acts as an inhibitor of inosine monophosphate dehydrogenase. It is used in the treatment of a variety of autoimmune diseases including granulomatosis with polyangiitis because the uptake of purine by actively dividing B cells can exceed 8 times that of normal body cells, and, therefore, this set of white cells (which cannot operate purine salvage pathways) is selectively targeted by the purine deficiency resulting from inherited metabolic diseases (IMD) inhibition.

 

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