Chemicals

hydrochlorothiazide

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Synonyms：

Hydrochlorothiazide

6-Chloro-3,4-Dihydro-(2H)-1,2,4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide

Molecular Formula: C7H8ClN3O4S2

Molecular weight：297.73900

Appearance and properties: white crystalline powder

Density: 1.693g/cm3

Boiling point: 577ºC at 760mmHg

Melting point: 273 °C

Flash point: 302.7ºC

Refractive index: 1.632

Stability: Stable. Incompatible with strong oxidizing agents.

Storage conditions: low temperature, ventilated and dry warehouse

Uses: Hydrochlorothiazide (English: Hydrochlorothiazide, referred to as HCTZ, HCT or HZT) is a diuretic. It is usually used to treat high blood pressure and edema caused by fluid accumulation. Other uses include the treatment of diabetes insipidus and renal tubular acidosis. It can also reduce hypercalciuria (English: Hypercalciuria), thereby reducing the risk of kidney stones.

Items of Analysis	Standard of Analysis	Test Results
Characters	White or practically white crystalline powder, practically odorless	Conforms
Soluble	Slightly soluble in water; freely soluble in sodium hydroxide solution, in n-butylamine, and in dimethylformamide; sparingly soluble in methanol; insoluble in ether, in chloroform, and in dilute mineral acids.	Conforms
Identification	IR,UV	Conforms
Loss on drying	≤0.5%	0.1%
Residue on ignition	≤0.1%	0.04%
Chloride	≤0.035%	Conforms
Selenium	≤0.003%	Conforms
Heavy metals	≤ 0.001%	Conforms
Related compounds	Benzothiadiazine related compound A ≤ 1.0%	0.4%
	Any other impurities≤ 0.5%	Conforms
	Total other impurities ≤0.9%	0.5%
Organic volatile impurities	Meets the requirements	Conforms
Assay	98.0~102.0%	100.1%
Conclusion	Conforms to USP42

hydrochlorothiazide

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