H3B-6527 Cas:1702259-66-2

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H3B-6527

Product Description:

Product Name: H3B-6527 CAS NO: 1702259-66-2

 

Synonyms:

N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)acrylamide;

Eisai/H3 Biomedicine;

 

Chemical & Physical Properties:

Appearance: Solid or powder

Assay :≥99.0%

Boiling Point: 832.1±65.0℃ (Predicted)

Density: 1.373±0.06 g/cm3 (Predicted)

PKa: 11.00±0.70 (Predicted)

Flash Point: 457.0±34.3℃

Vapor Pressure: 0.0±3.1 mmHg at 25℃

Index of Refraction: 1.665

 

H3B-6527 is a highly selective covalent FGFR4 inhibitor with an IC50<1.2nM, which is more than 250 times more selective for FGFR4 than for chemicalbook FGFR1-3 (IC50S for FGFR1-3 are 320NM, 1290NM and 1060NM, respectively).

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.



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