Faropenem Sodium Hemipentahydrate Cas:106560-14-9

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Product Description:

Product Name: Faropenem sodium hemipentahydrate CAS NO: 106560-14-9

 

Synonyms:

6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid;

(+)-(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;

 

Chemical & Physical Properties:

Appearance: Light yellow powder

Assay :≥99.0%

Density: 1.56g/cm3

Boiling Point: 570.2℃ at 760 mmHg

Flash Point: 298.7℃

Refractive Index: 1.668

Vapor Pressure: 2.23E-15mmHg at 25℃

 

Safety Information:

Risk Statements: R20/21/22

 

Farom was launched in Japan for use as an antibiotic against common respiratory tract pathogens. It can be prepared by several related routes of about seven steps starting with tetrahydrofuran-2-thiocarboxylic acid and a silylated azetidinone. It is a broad spectrum oral penem antibiotic that is β-lactamase stable. Farom is the most active β-lactam against anaerobes (more than cefaclor, cefixime and amoxicillin) but also has activity against Gram-positive, Gram-negative and enterobacteriaceae. It is equally active against strains carrying plasmid and chromosome mediated β-lactamases. The short plasma elimination half-life is the result of hydrolysis by renal dehydropeptidase. It is more stable to hydrolysis by extended spectrum β-lactamases than some second and third generation cephalosporins.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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