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Market News:As of June’s end, there have been 100 reported GBS cases among J&J recipients, most of whom were hospitalized and one person has died, CDC officials reported. Most cases were seen in older men within 13 days following the single-dose vaccine. 4-Methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentane-1,1-dicarboxylic acid dimethyl ester manufacturer.The company’s greenfield facility in Vasanthnarsapura Karnataka Industrial Area, Tumkur district, Karnataka, is under construction and is expected to be commissioned by April, 2022, well before the PLI scheme deadline of April 1, 2023. (Z)-3-(3-Bromo-phenyl)-3-hydroxy-dithioacrylic acid supplier.Professor Xiangdong Cheng, secretary of party committee of Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) and Chief of Zhejiang Province Upper Gastrointestinal Tumor Diagnosis and Treatment Technology Research Center, stated: The progress of immunotherapy in certain types of colorectal cancer and gastric cancer has not been satisfactory compared with the progress of anti-PD-1 monoclonal antibodies in melanoma, lung cancer and esophageal cancer, and this needs further exploration.
TIGIT is highly expressed in gastric cancer. And pre-clinical experiments have proved that synergistically targeting PD-1 and TIGIT could significantly repress gastric tumor growth. We look forward to the clinical results of IBI321, particularly in GI tumors.
Dr. Hui Zhou, Senior Vice President of Clinical Development of Innovent, stated: “By specifically targeting both PD-1 and TIGIT, this type of bispecific antibody is designed to provide synergistic effects by blocking both the PD-1/PD-L1 and TIGIT/CD155 pathways – with the goal of improving the anti-cancer efficacy.
Currently, there is no bispecific antibody that has same target as IBI321 in clinical-stage development worldwide. Preclinical studies of IBI321 have demonstrated that the combination of these two monoclonal antibodies further enhanced the immune activation with improved convenience of administration.
Therefore, the development of an anti-PD-1/TIGIT bispecific antibody has the potential to provide patients with more effective and convenient treatment. We look forward to hope that IBI321 will benefit more patients. [6,15-bis-13C]-ethyl 3,7,11-trimethyldodeca-2(E),6(E),10-trienoate producer.