Ethyl acetoacetate

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CAS No: 141-97-9
Product Name: Ethyl acetoacetate
Other Name:
Ethyl acetoacetate
Ethyl 3-oxobutanoate
3-Oxobutyric acid ethyl ester
 
Density: 1.0±0.1 g/cm3
Boiling Point: 180.6±8.0 °C at 760 mmHg
Melting Point: −43 °C(lit.)
Molecular Formula: C6H10O3
Molecular Weight: 130.142
Flash Point: 67.0±18.5 °C
Exact Mass: 130.062988
PSA: 43.37000
LogP: 0.72
Vapour density: 4.48 (vs air)
Vapour Pressure: 0.9±0.3 mmHg at 25°C
Index of Refraction: 1.408
Stability: Stable. Incompatible with acids, bases, oxidizing agents, reducing agents, alkali metals. Combustible.
Water Solubility: 116 g/L (20 ºC)
 
Specification
Appearance: Colorless to yellow liquid
Assay: ≥99.0%
Loss on drying: ≤0.5%
Acid value: ≤5.0
 
Application
Intermediates of Pirimiphos ethyl CAS: 23505-41-1.
Intermediates of Pirimiphos-methyl CAS: 29232-93-7.
Intermediates of Imazethapyr CAS: 81335-77-5.
Intermediates of Furametpyr CAS: 123572-88-3.
Intermediates of Diflumetorim CAS: 130339-07-0.
Intermediates of Cyprodinil CAS: 121552-61-2.
Intermediates of Warfarin CAS: 81-81-2.
Intermediates of Coumatetralyl CAS: 5836-29-3.
Intermediates of Hymexazol CAS: 10004-44-1.
Intermediates of Pirimcard CAS: 23103-98-2.
Intermediates of Diazinon CAS: 333-41-5.
Intermediates of Pirimioxyphos CAS: 36378-61-7.
Intermediates of Coumaphos CAS: 56-72-4.
Ethyl acetoacetate is an important raw material for organic synthesis. It is used in the production of pesticides to synthesize the organophosphorus insecticide fly phosphorus intermediate α-chloroacetoacetic acid ethyl acetate and the intermediate 2-methoxypyrimothion Methyl-4-methyl-6-hydroxypyrimidine, the intermediate of diazinon 2-isopropyl-4-methyl-6-hydroxypyrimidine and the carbamate insecticide pirimicarb , Herbicide azamethacin, rodenticide rodenticide, rodentin, etc., are also new fungicide varieties cyprodinil, difulmetorim, furammetpyr and An intermediate of plant growth regulator cintofen. In addition, ethyl acetoacetate is used as a solvent for lacquer and an analytical reagent. It is also widely used in medicine, plastics, dyes, spices, varnishes and additives.
The specificity of EAA structure determines both its ketone and enol reaction characteristics, and its chemical properties are very lively. It is widely used in medicine, dyes, pesticides and other fields. It is also used in food additives and flavors. The largest use of EAA in China is to synthesize medicine and its intermediates, mainly to synthesize γ-acetylbutyrolactone (an important intermediate of vitamin B), 4-methyl-7-hydroxycoumarin (an anti-allergic drug Intermediates), etc .; also used to prepare acetoacetyl-o-chloroaniline (intermediate for the synthesis of 1,3,5-pyrazolone and Hansa Yellow Lake), acetylacetyl-o-methylaniline (for the synthesis of organic yellow Dye packaging synergistic pigment yellow) and other dye intermediates; in addition, EAA is also used to produce pesticides such as methylpyrimidin phosphorus, pyrimidine phosphorus and so on.
Ethyl acetoacetate is widely used in organic synthesis. For example, it can be used to synthesize heterocyclic compounds such as pyridine, pyrrole, pyrazolone, pyrimidine, purine and cyclic lactone. It is also widely used in drug synthesis. For example, ethyl acetoacetate and resorcinol are cyclized to obtain 4-methyl-7-hydroxycoumarin, which is an anti-allergic scale intermediate. Condensation of ethyl acetoacetate and chlorobenzyl to obtain α-acetylphenylpropionate, which is an intermediate of cough ketones. Ethyl acetoacetate is condensed with benzoyl chloride to give ethyl benzoylacetate, which is an intermediate of the central stimulant Campanula hydrochloride. Ethyl acetate is cyclized with thiourea to prepare the antithyroid drug methionine (which is an intermediate of coronary dilatation agent persantin).
 
Package: 25kg/drum, can also be designed according to customer requirements.
Storage: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Ethyl acetoacetate


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