Eserine Salicylate Cas:57-64-7

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Eserine Salicylate

[(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate, 2-hydroxybenzoic acid
Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl N-methylcarbamate (1:1)
Molecular Formula: C22H27N3O5
Molecular weight: 413.46700
Appearance and properties: colorless crystal, odorless
Boiling point: 393.5ºC at 760 mmHg
Melting point: 181-183 °C
Flash point: 191.8ºC
Uses: Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate can penetrate the blood-brain barrier and stimulate central cholinergic neurotransmission. Physostigmine salicylate reverses memory deficits in Alzheimer's disease transgenic mice. Physostigmine salicylate is also an antidote for anticholinergic poisoning.

Items of Analysis Standard of Analysis Test Results
Appearance White or white crystalline powder Conform
Identification HNMR Conform
Heavy metal ≤20ppm Conform
Residue on lgnition ≤0.2% 0.06%
Loss on drying ≤1.0% 0.56%
Purity (by HPLC) ≥98.0% 98.97%
Conclusion Conforms to Factory Standard

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