ER-886046-00 Cas:1369489-71-3

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Product Description:

Product Name: ER-886046-00 CAS NO: 1369489-71-3

 

Synonyms:

(S)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)benzoic acid;

E7046;

Benzoicacid,4-[(1S)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl]carbonyl]amino]ethyl]-;

 

Chemical & Physical Properties:

Appearance: Solid or powder

Assay :≥99.0%

Density: 1.43±0.1 g/cm3(Predicted)

Boiling Point: 594.8±50.0℃(Predicted)

Flash Point: 313.5±30.1℃

PKa: 4.17±0.10 (Predicted)

Vapor Pressure: 0.0±1.8 mmHg at 25℃

Index of Refraction: 1.564

 

E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities. E-7046 is a specific antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4 (IC₅₀ = 13.5 nM). It possesses significant antitumor growth activity in multiple preclinical tumor models through modulating myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells.

 

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