Entacapone Cas:130929-57-6

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Product Description:

Product Name: Entacapone CAS NO: 130929-57-6    

 

Synonyms:

Comtess;

OR-611;

2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide;

 

Chemical & Physical Properties:

Appearance: Yellow crystalline solid

Assay :≥99.00%

Density: 1.392g/cm3

Boiling Point: 526.6℃ at 760 mmHg

Melting Point: 162-163℃

Flash Point: 272.3℃

Refractive Index: 1.641

Vapor Pressure: 1.05E-11mmHg at 25℃

 

Safety Information:

RTECS: KM5250000

Hazard Class: 3

Safety Statements: S26; S36; S39; S45

HS Code: 2942000000

WGK Germany: 1

Packing Group: III

RIDADR: UN 1986 3/PG 3

Risk Statements: R10; R20/21/22; R37/38; R41; R62; R38; R36/37/38

Hazard Codes: Xn; T; F

 

Entacapone (INN) is a medication commonly used in combination with other medications for the treatment of Parkinson”s disease. Entacapone together with levodopa and carbidopa allows levodopa to have a longer effect in the brain and reduces Parkinson’s disease signs and symptoms for a greater length of time than levodopa and carbidopa therapy alone.

Entacapone is known as a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT). When taken together with levodopa (L-DOPA) and carbidopa, entacapone stops catechol-O-methyltransferase from breaking down and metabolizing levodopa, resulting in an overall increase of levodopa remaining in the brain and body.

Entacapone is developed by Orion Pharma and marketed by Novartis under the trade name Comtan. Stalevo, another medication developed by Orion Pharma and marketed by Novartis, is a single tablet formulation that contains levodopa, carbidopa, and entacapone.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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