Dipyridamole Cas:58-32-2

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Product Description:

Product Name: Dipyridamole CAS NO: 58-32-2

 

Synonyms:

2,2”,2””,2”””-((4,8-Di(piperidin-1-yl)pyrimido[5,4-d]-pyrimidine-2,6-diyl)bis(azanetriyl))tetraet;

Corosan;

Coroxin;

 

Chemical & Physical Properties:

Appearance: Yellow Powder

Assay :≥99.0%

Density: 1.352 g/cm3

Boiling Point: 806.5℃ at 760 mmHg

Melting Point: 165-166℃

Flash Point: 441.5℃

Refractive Index: 1.666

Stability: Stable at normal temperatures and pressures. Sensitive to light.

Storage Condition: -20℃

 

Safety Information:

Safety Statements: S26-S36

HS Code: 2933990090

WGK Germany: 2

Risk Statements: R36/37/38

Hazard Code: Xi

Signal Word: Warning

Caution Statement: P261; P305 + P351 + P338

Hazard Declaration: H315; H319; H335

Symbol: GHS07

 

Dipyridamole (trademarked as Persantine) is a medication that inhibits blood clot formation when given chronically and causes blood vessel dilation when given at high doses over a short time. Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.Target: Phosphodiesterase (PDE)Dipyridamole concentrations of 1 nmol/ml blood caused 90% inhibition of adenosine metabolism. Dipyridamole at therapeutic concentrations causes significant inhibition of adenosine metabolism in whole blood. Dipyridamole has a dose-dependent inhibitory effect on thromboxane synthesis which was independent of aggregation. Dipyridamole also inhibited malonyldialdehyde production in response to both thrombin and arachidonic acid. Dipyridamole enhances platelet inhibition by amplifying the signaling of the NO donor sodium nitroprusside. These data support the concept that enhancement of endothelium-dependent NO/cGMP-mediated signaling may be an important in vivo component of dipyridamole action.

 

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