Cytarabine Cas:147-94-4

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Product Description:

Product Name: cytarabine CAS NO: 147-94-4

 

Synonyms:

Cytosine β-D-Arabinofuranoside;

4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone;

4-Amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;

 

Chemical & Physical Properties:

Appearance: Off-white crystalline powder

Assay :≥99.0%

Density: 1.89 g/cm3

Boiling Point: 545.7℃ at 760 mmHg

Melting Point: 212 – 213℃

Flash Point: 283.8℃

Refractive Index: 1.756

Stability: Stable

Storage Condition: 2-8℃

Vapor Pressure: 3.5E-14mmHg at 25℃

Water Solubility: Almost transparency

 

Safety Information:

Signal Word: Warning

Symbols: GHS07, GHS08

Safety Statements: S36/37

HS Code: 2934999090

WGK Germany: 3

RTECS: HA5425000

Risk Statements: R43; R63

Hazard Codes: Xn,Xi

Hazard Declaration: H317; H361

Caution Statement: P280

 

Cytarabine or cytosine arabinoside (Cytosar-U or Depocyt) is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It is also known as ara-C (arabinofuranosyl cytidine). It kills cancer cells by interfering with DNA synthesis.

It is called cytosine arabinoside because it combines a cytosine base with an arabinose sugar. Cytosine normally combines with a different sugar, deoxyribose, to form deoxycytidine, a component of DNA. Certain sponges, where it was originally found, use arabinoside sugars to form a different compound (not part of DNA). Cytosine arabinoside is similar enough to human cytosine deoxyribose (deoxycytidine) to be incorporated into human DNA, but different enough that it kills the cell. This mechanism is used to kill cancer cells. Cytarabine is the first of a series of cancer drugs that altered the sugar component of nucleosides. Other cancer drugs modify the base.

It is on the World Health Organization”s List of Essential Medicines, a list of the most important medication needed in a basic health system.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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