Cyproterone Acetate Cas:427-51-0

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Product Description:

Product Name: Cyproterone acetate CAS NO: 427-51-0

 

Synonyms:             

Cyproterone 17-O-acetate;

Cyproteron acetate;

20-dione,6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-pregna-6-diene-3;

 

Chemical & Physical Properties:

Appearance: Crystalline Solid

Assay :≥99.0%

Density: 1.27 g/cm3

Boiling Point: 525.9℃ at 760 mmHg

Melting Point: 200-201℃

Flash Point: 177.6℃

Refractive Index: 1.582

Storage Condition: 2-8℃

Vapor Pressure: 3.78E-11mmHg at 25℃

 

Safety Information:

RTECS: GZ2230000

Safety Statements: S26-S36

HS Code: 2937290090

WGK Germany: 3

Risk Statements: R20/21/22; R40

Hazard Codes: Xn,Xi

 

The free alcohol is an anti-androgen; the acetate is both an anti-androgen and a progestogen. Combined with estrogen it is used in the treatment of acne. Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity. Target: Androgen ReceptorCyproterone acetate clearly shows antagonistic properties, while being a partial agonist also, showing agonism for the AR, with EC50 of 4.0 μM, at relatively high concentrations. In the presence of 10 nM Testosterone, low concentrations of Cyproterone acetate inhibits T-stimulated transcription of 3XHRE-LUC, but at higher concentrations, transcription is stimulated. LH levels in Cyproterone acetate-treated rats do not dip below pretreatment levels, although they does not increase as much in the rats treated with 3.2 mg Cyproterone acetate/kg/day as in those which received 0.2 mg Cyproterone acetate/kg/day. Cyproterone acetate exhibits direct negative effect on reproductive organs weight and significant reducing effect on sperm count and Ca2+ contents. SOD and GST activities significantly decrease in addition to significant increase in NO, MDA contents reflecting the oxidative status of testis in Cyproterone acetate treated rats.

 

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