Cisatracurium Besylate Cas:96946-42-8

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Product Description:

Product Name: cisatracurium besylate CAS NO: 96946-42-8

 

Synonyms:

Cisatracurium bes (Cisatracuriumbesylate/Clotrimazole);

Cis-AttacuriuM;

cisatracurium besilate;

 

Chemical & Physical Properties:

Appearance: White solid

Assay :≥99.0%

Melting Point: 90-93℃

Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere

Solubility: H2O: soluble1mg/mL

 

Safety Information:

HS Code: 2914509090

Hazard Code:  T

Risk Statements: R25-36

Safety Statement: S45

RIDADR: UN 2811 6.1 / PGIII

WGK Germany: 3

 

Cisatracurium (formerly recognized as 51W89, and marketed as Nimbex) is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is a bisbenzyltetrahydroisoquinolinium agent with an intermediate duration of action. Cisatracurium is one of the ten isomers of the parent molecule, atracurium. Moreover, cisatracurium represents approximately 15% of the atracurium mixture.

Cisatracurium besylate is a new intermediate-duration non-depolarizing muscle relaxant launched in the U.S.A. for intubation and maintenance of muscle relaxation during surgery and intensive care. Cisatracurium besylate is the single 1 R cis-1”R cis isomer of the commercial preparation of atracurium, a mixture of 10 isomers. It is 3 to 5 times more potent than the mixture with similar onset and duration of action. The single isomer was also reported to have reduced propensity to release histamine and have a stable cardiovascular profile. Similar to structurally related mivacurium, cisatracurium has distinct advantages of rapid degradation, enzymatic metabolism that is independent of liver or kidney resulting in short duration of action and fast, complete recovery.

 

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