CALCIUM MALATE Cas:17482-42-7

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DL-malic acid,calcium-DL malate
calcium hydrogenmalate
calcium 2-hydroxysuccinate
2-Hydroxybutanedioic acid calcium salt
calcium 2-hydroxybutanedioate
Apple calciuM
Molecular Formula: C4H4CaO5
Molecular weight: 172.15000
Appearance and properties: off-white powder
Boiling point: 306.4ºC at 760 mmHg
Flash point: 153.4ºC
Vapor pressure: 7.19E-05mmHg at 25°C
Stability: Stable at room temperature in closed containers under normal storage and handling conditions.
Storage conditions: Store in a cool, dry place. Store in a tightly closed container.
Uses: used in medical health to supplement the calcium required by the human body, etc.


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TIGIT is highly expressed in gastric cancer. And pre-clinical experiments have proved that synergistically targeting PD-1 and TIGIT could significantly repress gastric tumor growth. We look forward to the clinical results of IBI321, particularly in GI tumors.
Dr. Hui Zhou, Senior Vice President of Clinical Development of Innovent, stated: “By specifically targeting both PD-1 and TIGIT, this type of bispecific antibody is designed to provide synergistic effects by blocking both the PD-1/PD-L1 and TIGIT/CD155 pathways – with the goal of improving the anti-cancer efficacy.
Currently, there is no bispecific antibody that has same target as IBI321 in clinical-stage development worldwide. Preclinical studies of IBI321 have demonstrated that the combination of these two monoclonal antibodies further enhanced the immune activation with improved convenience of administration.
Therefore, the development of an anti-PD-1/TIGIT bispecific antibody has the potential to provide patients with more effective and convenient treatment. We look forward to hope that IBI321 will benefit more patients. (2-Nitro-benzyl)-phosphoramidic acid (2R,3S,5S)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5S)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl este producer.

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