Brinzolamide Cas:138890-62-7

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Product Description

Product Name: Brinzolamide CAS NO: 138890-62-7

 

Synonyms:

(R)-(+)-4-ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide-1,1-dioxide;

Birnzolamide;

Brinzolamide (BRZ);

3znc;Azopt;Azopt (TN);

(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide;

 

Chemical & Physical Properties

Appearance : White to off-white powder

Assay :≥99.0%

Density:1.5 g/cm3

Boiling Point:586℃ at 760 mmHg

Melting Point: 130-134℃

Flash Point:308.2℃

 

Brinzolamide (trade names Azopt, Alcon Laboratories, Befardin, Fardi Medicals, ) is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Brinzolamide was introduced as Azopt in the US for the treatment of elevated intraocular pressure (IOP) in patients with ocular hypertension or openangle glaucoma. Brinzolamide is a potent inhibitor of human carbonic anhydrase Ⅱ lowering IOP after topical administration . It is the second of this class after dorzolamide (1995). Brinzolamide can be prepared in an eight-step sequence from 3-acetyl-2,5-dichlorothiophene. In patients with primary open-angle glaucoma or ocular hypertension, brinzolamide produced significant reductions in IOP and showed less ocular discomfort than dorzolamide.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

 

 

 

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