BMS-986195 Cas:1912445-55-6

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Product Description:

Product Name: BMS-986195 CAS NO: 1912445-55-6

 

Synonyms:

1H-Indole-7-carboxamide,5-fluoro-2,3-dimethyl-4-[(3S)-3-[(1-oxo-2-butyn-1-yl)amino]-1-piperidinyl]-;

(S)-4-(3-(2-Butynoylamino)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide;

5-Fluoro-2,3-dimethyl-4-[(3S)-3-[(1-oxo-2-butyn-1-yl)amino]-1-piperidinyl]-1H-indole-7-carboxamide;

 

Chemical & Physical Properties:

Appearance: Solid or powder

Assay :≥98.0%

Density: 1.32±0.1 g/cm3 (Predicted)

PKa: 11.91±0.20 (Predicted)

Storage Conditions: -20℃

 

Branebrutinib (BMS-986195) is an effective BTK inhibitor with IC50 values of 0.1 nM, 0.9 nM, 1.5 nM, and 5 nM for BTK, TEC, BMX, and TXK, respectively. BMS-986195 is a potent, covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK), with an IC50 of <1 nM.

 

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.

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