Azilsartan KaMedoxoMil Cas:863031-24-7

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Product Description:

Product Name: Azilsartan kaMedoxoMil CAS NO: 863031-24-7

 

Synonyms:

1H-Benzimidazole-7-carboxylic acid, 1-((2”-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3- yl)(1,1”-biphenyl)-4-yl)methyl)-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, potassium salt;

Azilsartan medoxomil monopotassium;

potassium,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl2-ethoxy-3-[[4-[2-(5-oxo-1-oxa-2-aza-4-azanidacyclopent-2-en-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate;

 

Chemical & Physical Properties:

Appearance: White or off-white powder

Assay :≥99.00%

Water Solubility: Insoluble

Soluble: DMSO, Methanol

 

Azilsartan kamedoxomil, developed by Takeda Pharmaceuticals, was approved for the treatment of hypertension and launched in the U.S. under the brand name Edarbi. Edarbi is a prodrug that undergoes rapid hydrolysis to liberate azilsartan, the active ingredient (TAK-536, 39). As the 8th angiotensin receptor blocker (ARB) to enter the world market, azilsartan kamedoxomil can function as monotherapy or in combination with other antihypertensive agents. In several clinical studies, monotherapeutic azilsartan kamedoxomil showed superior antihypertensive activity and a favorable safety/tolerability profile in patients compared with other established therapeutics, including valsartan, olmesartan medoxomil, candesartan, and telmisartan.In late 2011,Takeda announced that FDA also approved the fixed-dose combination tablet of azilsartan kamedoxomil with chlorthalidone under the trade name of Edarbyclor.

 

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