Azilsartan Cas:147403-03-0

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Product Description:

Product Name: Azilsartan CAS NO: 147403-03-0      

                    

Synonyms:

TAK 536;

1H-Benzimidazole-7-carboxylicacid,1-[[2”-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1”-biphenyl]-4-yl]methyl]-2-ethoxy;

2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid;

 

Chemical & Physical Properties:

Appearance: White to beige powder           

Assay :≥99.0%

Density: 1.42

Melting Point: 188℃(dec.)

Storage Temp.: 2-8℃

Solubility: DMSO: soluble15mg/mL (clear solution)

 

Safety Information:

WGK Germany: 3

 

Edarbi (azilsartan medoxomil), a prodrug, is hydrolyzed to azilsartan in the gastrointestinal tract during absorption. Azilsartan is a selective AT1 subtype angiotensin II receptor antagonist. The drug substance used in the drug product formulation is the potassium salt of azilsartan medoxomil, also known by the US accepted name of azilsartan kamedoxomil and is chemically described as (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2”-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate monopotassium salt. Azilsartan and chlorthalidone combination is used to treat high blood pressure (hypertension). Azilsartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to tighten. As a result, azilsartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart. Azilsartan is an analgesic and antiinflammatory drugs containing angiotensin II antagonists.

 

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