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Product Description:
Product Name: azetidin-3-ol,hydrochloride CAS NO: 18621-18-6
Synonyms:
3-hydroxyazetidine monohydrochloride;
3-Hydroxyazetidine-HCl;
3-Azetidinol Hydrochloride;
Chemical & Physical Properties:
Appearance: White crystal
Assay :≥98.0%
Boiling Point: 170.7℃ at 760 mmHg
Melting Point: 85-90℃
Flash Point: 120.4℃
Vapor Pressure: 0.464mmHg at 25℃
Storage Temp.: Room temperature
Water Solubility: Soluble in water, DMSO, methanol
Sensitive: Hygroscopic
Safety Information:
Hazard Codes: C; Xi; Xn
HS Code: 2933990090
Risk Statements: R36/37/38
Safety Statements: S26; S36/37/39
A useful intermediate in the synthesis of polypeptides. 3- hydroxyazacyclobutane hydrochloride is an important intermediate for the synthesis of baricotinib, which is finally obtained through multiple reactions. Baricotinib is approved in the European Union as a single agent or in combination with methotrexate for the treatment of adults with moderately to severely active rheumatoid arthritis who have inadequate or intolerant response to one or more anti-rheumatoid drugs (DMARDs). 3- hydroxyazacyclobutane hydrochloride is a hydrocarbon derivative and can be used as pharmaceutical intermediates.
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